Lennox appeared on stage at the 1988 Nelson Mandela 70th Birthday Concert and began activist work with the Sing Foundation afterwards. In 1990, Lennox did a version of Cole Porter's "Ev'ry Time We Say Goodbye" for the Cole Porter album Red Hot + Blue, a benefit for AIDS awareness. A video was produced.
Lennox has been a public supporter of Amnesty International and Greenpeace for many years. She and Dave Stewart donated all of the profits from Eurythmics' 1999 Peacetour to both charities.
Tibet
Concerned by Tibet freedom, she supported Amnesty International campaigns for the release of the Tibetan prisoners Palden Gyatso and Ngawang Choephel.
In 2006, in response to her humanitarian work, Lennox became a patron of the Master's Course in Humanitarian and Development Practice for Oxford Brookes University. In 2006, Lennox spoke at the British House of Commons about the need for British children to help their counterparts in Africa.
In April 2007, Lennox performed "Bridge over Troubled Water" during the American Idol "Idol Gives Back" fundraising drive.
Work with Mandela
Lennox's 2007 song "Sing" was born out of her involvement with Nelson Mandela's campaign and Treatment Action Campaign (TAC), both of which are human rights groups which seek education and health care for those affected by HIV.